성의학
글 수 140
성병에 의해서도 암이 걸릴 수 있다.
가장 흔한 성병인 비임균성요도염에 의해 자궁경부암을 일으킬 수 있다고 발표되었다. 클라미디아 성병에 걸린 여인들을 조사한 결과 10년 정도 지나 자궁경부암이 생기는 비율이 높다는 것이다. (자궁경부암은 한국여성에게 가장 많은 암중에 하나이다.)
10종의 클라미디아균 중에서 3종류(G형, I형, D형)가 암을 유발시켰으며 G형이 가장 높았다. 핀란드, 노르웨이, 스웨덴등 스칸디니비아 여성 53만명 중 자궁경부암에 걸린 사람을 대상으로 조사하였으며 암을 발생하기 1년 전부터 클라미디아 성병 감염이 있었는지를 비교분석하였다.
JAMA. 2001;285:47-51
Serotypes of Chlamydia trachomatis and Risk for Development of Cervical Squamous Cell Carcinoma
Tarja Anttila, MD; Pekka Saikku, MD; Pentti Koskela, PhD; Aini Bloigu, BSc; Joakim Dillner, MD; Irma Ikaheimo, PhD; Egil Jellum, PhD; Matti Lehtinen, MD; Per Lenner, MD; Timo Hakulinen, PhD; Ale Narvanen, PhD; Eero Pukkala, PhD; Steinar Thoresen, MD; Linda Youngman, PhD; Jorma Paavonen, MD
Context: Human papillomavirus (HPV) infection has been established as a cause of cervical cancer. Epidemiologic studies suggest that Chlamydia trachomatis infection also confers increased risk for cervical squamous cell carcinoma (SCC). Whether this risk is serotype-specific is unknown.
Objective: To study the association between exposure to different C trachomatis serotypes and subsequent development of cervical SCC.
Design and Setting: Longitudinal, nested case-control study within a cohort of 530 000 women who provided samples to serum banks in Finland, Norway, and Sweden. The data files were linked to respective national cancer registries.
Subjects: One hundred twenty-eight women who had developed invasive cervical SCC at least 12 months following serum donation. Each case had 3 matched controls.
Main Outcome Measure: Risk for the development of cervical SCC by IgG antibodies to 10 different C trachomatis serotypes, adjusted for antibodies to HPV types 16, 18, and 33 and for serum cotinine levels.
Results: Of specific C trachomatis serotypes, serotype G was most strongly associated with SCC (adjusted odds ratio [OR], 6.6; 95% confidence interval [CI], 1.6-27.0). Other serotypes associated with SCC were I (OR, 3.8; 95% CI, 1.3-11.0) and D (OR, 2.7; 95% CI, 1.3-5.6). Presence of serum IgG antibodies to more than 1 serotype increased the adjusted ORs for SCC (P<.001 for trend).
Conclusions: Chlamydia trachomatis serotype G is most strongly associated with subsequent development of cervical SCC. Increasing numbers of exposures to different C trachomatis serotypes also increases risk. Our results strengthen the evidence that there is a link between past C trachomatis infection and cervical SCC.
JAMA. 2001;285:47-51
가장 흔한 성병인 비임균성요도염에 의해 자궁경부암을 일으킬 수 있다고 발표되었다. 클라미디아 성병에 걸린 여인들을 조사한 결과 10년 정도 지나 자궁경부암이 생기는 비율이 높다는 것이다. (자궁경부암은 한국여성에게 가장 많은 암중에 하나이다.)
10종의 클라미디아균 중에서 3종류(G형, I형, D형)가 암을 유발시켰으며 G형이 가장 높았다. 핀란드, 노르웨이, 스웨덴등 스칸디니비아 여성 53만명 중 자궁경부암에 걸린 사람을 대상으로 조사하였으며 암을 발생하기 1년 전부터 클라미디아 성병 감염이 있었는지를 비교분석하였다.
JAMA. 2001;285:47-51
Serotypes of Chlamydia trachomatis and Risk for Development of Cervical Squamous Cell Carcinoma
Tarja Anttila, MD; Pekka Saikku, MD; Pentti Koskela, PhD; Aini Bloigu, BSc; Joakim Dillner, MD; Irma Ikaheimo, PhD; Egil Jellum, PhD; Matti Lehtinen, MD; Per Lenner, MD; Timo Hakulinen, PhD; Ale Narvanen, PhD; Eero Pukkala, PhD; Steinar Thoresen, MD; Linda Youngman, PhD; Jorma Paavonen, MD
Context: Human papillomavirus (HPV) infection has been established as a cause of cervical cancer. Epidemiologic studies suggest that Chlamydia trachomatis infection also confers increased risk for cervical squamous cell carcinoma (SCC). Whether this risk is serotype-specific is unknown.
Objective: To study the association between exposure to different C trachomatis serotypes and subsequent development of cervical SCC.
Design and Setting: Longitudinal, nested case-control study within a cohort of 530 000 women who provided samples to serum banks in Finland, Norway, and Sweden. The data files were linked to respective national cancer registries.
Subjects: One hundred twenty-eight women who had developed invasive cervical SCC at least 12 months following serum donation. Each case had 3 matched controls.
Main Outcome Measure: Risk for the development of cervical SCC by IgG antibodies to 10 different C trachomatis serotypes, adjusted for antibodies to HPV types 16, 18, and 33 and for serum cotinine levels.
Results: Of specific C trachomatis serotypes, serotype G was most strongly associated with SCC (adjusted odds ratio [OR], 6.6; 95% confidence interval [CI], 1.6-27.0). Other serotypes associated with SCC were I (OR, 3.8; 95% CI, 1.3-11.0) and D (OR, 2.7; 95% CI, 1.3-5.6). Presence of serum IgG antibodies to more than 1 serotype increased the adjusted ORs for SCC (P<.001 for trend).
Conclusions: Chlamydia trachomatis serotype G is most strongly associated with subsequent development of cervical SCC. Increasing numbers of exposures to different C trachomatis serotypes also increases risk. Our results strengthen the evidence that there is a link between past C trachomatis infection and cervical SCC.
JAMA. 2001;285:47-51
